USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: O00217 USC-OGP 2-DE database:  O00217 O00217 General information about the entry View entry in simple text format Entry name NDUS8_HUMAN Primary accession number O00217 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; EC=1.6.5.3; EC=1.6.99.3; AltName: Full=Complex I-23kD; Short=CI-23kD; AltName: Full=NADH-ubiquinone oxidoreductase 23 kDa subunit; AltName: Full=TYKY subunit; Flags: Precursor;. Gene name Name=NDUFS8 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0561: pI=5.11; Mw=21509 Cross-references UniProtKB/Swiss-Prot O00217; NDUS8_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name NDUS8_HUMAN Primary accession number O00217 Secondary accession number(s) B2RB86 Q0VDA8 Sequence was last modified on  July 1, 1997 (version 1) Annotations were last modified on  March 15, 2017 (version 167) Name and origin of the protein Description RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; EC=1.6.5.3; EC=1.6.99.3; AltName: Full=Complex I-23kD; Short=CI-23kD; AltName: Full=NADH-ubiquinone oxidoreductase 23 kDa subunit; AltName: Full=TYKY subunit; Flags: Precursor; Gene name Name=NDUFS8 Encoded on Name=NDUFS8 Keywords 4Fe-4S; Complete proteome; Disease mutation; Electron transport; Iron; Iron-sulfur; Leigh syndrome; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Repeat; Respiratory chain; Transit peptide; Transport; Ubiquinone. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U65579; AAB51776.1; -; mRNA EMBL AF038406; AAC34273.1; -; Genomic_DNA EMBL AK314546; BAG37133.1; -; mRNA EMBL BC119754; AAI19755.1; -; mRNA CCDS CCDS8176.1; -; . RefSeq NP_002487.1; NM_002496.3; . RefSeq XP_005274070.1; XM_005274013.1; . RefSeq XP_005274071.1; XM_005274014.2; . RefSeq XP_011543355.1; XM_011545053.2; . UniGene Hs.90443; -; . ProteinModelPortal O00217; -; . SMR O00217; -; . BioGrid 110806; 58; . IntAct O00217; 22; . MINT MINT-2997478; -; . STRING 9606.ENSP00000315774; -; . ChEMBL CHEMBL2363065; -; . DrugBank DB00157; NADH; . iPTMnet O00217; -; . PhosphoSitePlus O00217; -; . SwissPalm O00217; -; . BioMuta NDUFS8; -; . OGP O00217; -; . EPD O00217; -; . MaxQB O00217; -; . PaxDb O00217; -; . PeptideAtlas O00217; -; . PRIDE O00217; -; . TopDownProteomics O00217; -; . Ensembl ENST00000313468; ENSP00000315774; ENSG00000110717; . GeneID 4728; -; . KEGG hsa:4728; -; . UCSC uc001onc.4; human; . CTD 4728; -; . DisGeNET 4728; -; . GeneCards MIR4691; -; . GeneCards MIR7113; -; . GeneCards NDUFS8; -; . HGNC HGNC:7715; NDUFS8; . HPA HPA018524; -; . MalaCards NDUFS8; -; . MIM 256000; phenotype; . MIM 602141; gene; . neXtProt NX_O00217; -; . OpenTargets ENSG00000110717; -; . Orphanet 2609; Isolated NADH-CoQ reductase deficiency; . Orphanet 255241; Leigh syndrome with leukodystrophy; . PharmGKB PA31525; -; . eggNOG KOG3256; Eukaryota; . eggNOG COG1143; LUCA; . GeneTree ENSGT00390000003049; -; . HOGENOM HOG000228289; -; . HOVERGEN HBG006547; -; . InParanoid O00217; -; . KO K03941; -; . OMA RGDLYYT; -; . OrthoDB EOG091G0OQD; -; . PhylomeDB O00217; -; . TreeFam TF105610; -; . Reactome R-HSA-611105; Respiratory electron transport; . Reactome R-HSA-6799198; Complex I biogenesis; . GeneWiki NDUFS8; -; . GenomeRNAi 4728; -; . PRO PR:O00217; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000110717; -; . CleanEx HS_NDUFS8; -; . ExpressionAtlas O00217; baseline and differential; . Genevisible O00217; HS; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0051539; F:4 iron; 4 sulfur cluster binding; IEA:UniProtKB-KW GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB; . GO GO:0006120; P:mitochondrial electron transport; NADH to ubiquinone; NAS:UniProtKB GO GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB; . GO GO:0006979; P:response to oxidative stress; IDA:UniProtKB; . HAMAP MF_01351; NDH1_NuoI; 1; . InterPro IPR017896; 4Fe4S_Fe-S-bd; . InterPro IPR017900; 4Fe4S_Fe_S_CS; . InterPro IPR010226; NADH_quinone_OxRdtase_chainI; . Pfam PF12838; Fer4_7; 1; . TIGRFAMs TIGR01971; NuoI; 1; . PROSITE PS00198; 4FE4S_FER_1; 2; . PROSITE PS51379; 4FE4S_FER_2; 2; .

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• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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